Lipocalin allergen Bos d 2 is a weak immunogen
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چکیده
منابع مشابه
Rubella virus nonstructural protein 2 is a minor immunogen.
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متن کاملDimerization of lipocalin allergens
Lipocalins are one of the most important groups of inhalant animal allergens. The analysis of structural features of these proteins is important to get insights into their allergenicity. We have determined two different dimeric crystal structures for bovine dander lipocalin Bos d 2, which was earlier described as a monomeric allergen. The crystal structure analysis of all other determined lipoc...
متن کاملT cell epitopes of a lipocalin allergen colocalize with the conserved regions of the molecule.
In this study we characterized the human T cell-reactive sites of the major cow dander allergen, Bos d 2, a member of the lipocalin protein family. We showed that Bos d 2 contains only a limited number of epitopes. This is in contrast to many other allergens, which usually contain multiple T cell epitopes throughout the molecule. The epitopes of Bos d 2 were primarily concentrated in the conser...
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Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cogniti...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2002
ISSN: 1460-2377,0953-8178
DOI: 10.1093/intimm/14.4.401